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. 2013 Nov 25;3:78. doi: 10.1186/2191-219X-3-78

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Copyright © 2013 Zanotti-Fregonara et al.; licensee Springer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Regression analyses for V_Tresults obtained from the 13 brain regions of a 23-year-old subject. (A) Spectral analysis (filled square) provided good results with a very small bias (+1.4%). Logan (empty circle) and MA1 (filled circle) slightly underestimated V_T values (-7.4% and -9.7%, respectively, for this subject). At the voxel level (B), only SA provided results with a small bias and good correlation with 2TCM (0.932x + 1.793, R² = 0.92, p < 0.0001). In contrast, Logan_voxel underestimated V_T values by about 47% (0.324x + 2.61, R² = 0.32, p = 0.047).