Table 1.
RNA copies altered in LN of RT-SHIV-infected macaques, but normal in ART-suppressed RT-SHIV-infected macaques.
| Gene | Copy Number Average (SEM) | t Test p Values | Spearman Correlation p Values | ||||
|---|---|---|---|---|---|---|---|
| Uninfected | Infected | ART | Uninfected v. Infected | Infected v. ART | Uninfected v. ART | ||
| CCL17 | 230 (42) | 86 (22) | 155 (49) | 0.0054 | 0.0866 | 0.1796 | 0.1170 |
| CCL21 | 5479 (1230) | 2033 (502) | 6178 (4112) | 0.0108 | 0.0905 | 0.4224 | 0.0050 |
| CCR4 | 104 (23) | 40 (6) | 57 (3) | 0.0085 | 0.0604 | 0.0879 | 0.0596 |
| CD4 | 326 (25) | 203 (22) | 329 (111) | 0.0025 | 0.0789 | 0.4842 | 0.0006 |
| IL-1R | 55 (13) | 37 (3) | 52 (2) | 0.0951 | 0.0075 | 0.4334 | 0.1010 |
| LTB | 328 (37) | 208 (55) | 462 (315) | 0.0601 | 0.1442 | 0.2938 | 0.0233 |
| MAP2K6 | 54 (9) | 34 (5) | 44 (15) | 0.0335 | 0.2017 | 0.2861 | 0.0154 |
| MAPK8 | 64 (7) | 44 (2) | 52 (4) | 0.0064 | 0.0347 | 0.1196 | 0.0104 |
| MAPKAPK5 | 57 (6) | 45 (4) | 54 (17) | 0.0688 | 0.2385 | 0.4309 | 0.0833 |
| MYC | 199 (14) | 180 (16) | 262 (60) | 0.2020 | 0.0577 | 0.1144 | 0.0476 |
| NFATc3 | 214 (22) | 147 (12) | 211 (54) | 0.0105 | 0.0743 | 0.4751 | 0.0321 |
| TLR5 | 11 (3) | 6 (0.8) | 9 (2) | 0.0391 | 0.0292 | 0.3225 | 0.0650 |
| TRAF2 | 49 (4) | 38 (7) | 43 (16) | 0.1064 | 0.3687 | 0.3272 | 0.0454 |
| CCL3 | 26 (6) | 99 (18) | 27 (3) | 0.0032 | 0.0148 | 0.4511 | 0.0011 |
| CCL4 | 67 (11) | 192 (32) | 55 (16) | 0.0039 | 0.0120 | 0.2707 | 0.0208 |
| CCL5 | 24 (5) | 186 (25) | 17 (1) | 0.0001 | 0.0011 | 0.1399 | 0.0025 |
| CXCL9 | 360 (232) | 1433 (332) | 215 (95) | 0.0160 | 0.0210 | 0.3317 | 0.0023 |
| CXCL10 | 335 (224) | 743 (163) | 373 (22) | 0.0828 | 0.0826 | 0.4509 | 0.0305 |
| CCR5 | 19 (3) | 35 (6) | 13 (2) | 0.0324 | 0.0258 | 0.1324 | 0.0623 |
| CD8 | 199 (44) | 413 (53) | 143 (46) | 0.0073 | 0.0071 | 0.2185 | 0.0196 |
| FasL | 16 (3) | 29 (6) | 12 (3) | 0.0395 | 0.0416 | 0.1726 | 0.0356 |
| integrin αE | 4 (1) | 17 (4) | 5 (1) | 0.0104 | 0.0493 | 0.1408 | 0.0042 |
| IL-15 | 68 (12) | 35 (3) | 55 (9) | 0.0104 | 0.0187 | 0.2405 | 0.0050 |
| JUN | 27 (7) | 43 (8) | 26 (6) | 0.0794 | 0.1058 | 0.4753 | 0.0246 |
| STAT1 | 498 (154) | 684 (90) | 456 (13) | 0.1524 | 0.0646 | 0.4225 | 0.0936 |
Bold, p value < 0.05
Underline, RNA altered similarly in ileum