Table 3.
RNA copies downregulated in LN of both RT-SHIV-infected and ART-suppressed RT-SHIV-infected macaques.
| Gene | Copy Number Average (SEM) | t Test p Values | Spearman Correlation p Values* | ||||
|---|---|---|---|---|---|---|---|
| Uninfected | Infected | ART | Uninfected v. Infected | Infected v. ART | Uninfected v. ART | ||
| CCL22 | 29 (5) | 10 (3) | 15 (3) | 0.0017 | 0.1120 | 0.0374 | 0.0306 |
| CCR2 | 22 (5) | 11 (2) | 8 (4) | 0.0225 | 0.2733 | 0.0438 | 0.0277 |
| CCR7 | 582 (61) | 269 (51) | 315 (84) | 0.0016 | 0.3166 | 0.0199 | 0.1142 |
| CD40 | 153 (12) | 99(13) | 69 (9) | 0.0066 | 0.0796 | 0.0014 | 0.1375 |
| CD40L | 138 (10) | 61 (13) | 90 (20) | 0.0006 | 0.1214 | 0.0236 | 0.0144 |
| CREB-1 | 293 (23) | 214 (13) | 176 (24) | 0.0061 | 0.0868 | 0.0082 | 0.0226 |
| DAXX | 50 (4) | 39 (6) | 32 (6) | 0.0710 | 0.2458 | 0.0168 | 0.1359 |
| GRB2 | 244 (23) | 184 (11) | 134 (7) | 0.0162 | 0.0102 | 0.0058 | 0.1316 |
| HLA-DRA | 5049 (357) | 3893 (339) | 2876 (522) | 0.0220 | 0.0678 | 0.0059 | 0.1635 |
| HLA-DRB1 | 958 (452) | 28 (18) | 32 (15) | 0.0243 | 0.4463 | 0.0875 | 0.0112 |
| IL-6R | 194 (19) | 110 (12) | 115 (12) | 0.0017 | 0.3834 | 0.0125 | 0.0204 |
| IL-23A | 21 (2) | 10 (2) | 11 (5) | 0.0009 | 0.3516 | 0.0489 | 0.0393 |
| LTA | 13 (2) | 9 (1) | 5 (2) | 0.0614 | 0.0613 | 0.0218 | 0.1142 |
| MAP3K1 | 213 (30) | 142 (18) | 127 (16) | 0.0314 | 0.3103 | 0.0422 | 0.3560 |
| MAP3K5 | 152 (21) | 108 (11) | 116 (11) | 0.0423 | 0.3388 | 0.1310 | 0.1546 |
| MAP3K7 | 109 (7) | 81 (7) | 68 (12) | 0.0130 | 0.1721 | 0.0095 | 0.2483 |
| MEF2A | 120 (15) | 85 (6) | 77 (2) | 0.0232 | 0.2006 | 0.0375 | 0.1294 |
| MEF2C | 74 (9) | 54 (8) | 31 (7) | 0.0587 | 0.0593 | 0.0076 | 0.4348 |
| NFE2L2 | 114 (17) | 86 (10) | 82 (4) | 0.0762 | 0.3934 | 0.0978 | 0.3560 |
| NFKB1 | 113 (15) | 80 (10) | 72 (12) | 0.0432 | 0.3227 | 0.0507 | 0.3863 |
| NR3C1 | 179 (15) | 131 (19) | 99 (25) | 0.0443 | 0.1816 | 0.0126 | 0.3863 |
| PTK2 | 70 (7) | 50 (7) | 29 (10) | 0.0351 | 0.0634 | 0.0068 | 0.2608 |
| TLR6 | 86 (17) | 56 (4) | 54 (11) | 0.0440 | 0.4102 | 0.1095 | 0.1072 |
| TRADD | 90 (11) | 58 (4) | 49 (9) | 0.0075 | 0.1670 | 0.0192 | 0.0939 |
Bold, p value < 0.05
Underline, RNA also downregulated significantly in ileum