Table 4.
RNA copies altered in ileum of both RT-SHIV-infected macaques and ART-suppressed RT-SHIV-infected macaques.
| Gene | Copy Number Average (SEM) | t Test p Values | Spearman Correlation p Values* | ||||
|---|---|---|---|---|---|---|---|
| Uninfected | Infected | ART | Uninfected v. Infected | Infected v. ART | Uninfected v. ART | ||
| CD40 | 65 (21) | 37 (13) | 13 (3) | 0.1385 | 0.0856 | 0.0170 | 0.2696 |
| CD40L | 22 (3) | 6 (2) | 8 (4) | 0.0010 | 0.3735 | 0.0204 | 0.0255 |
| DAXX | 47 (10) | 20 (4) | 21 (2) | 0.0072 | 0.4357 | 0.0136 | 0.0138 |
| GRB2 | 180 (16) | 138 (15) | 87 (25) | 0.0603 | 0.0477 | 0.0174 | 0.0666 |
| HLA-DRB1 | 361 (257) | 60 (52) | 101 (43) | 0.0734 | 0.2932 | 0.1466 | 0.3586 |
| MAP3K5 | 87 (20) | 61 (5) | 47 (8) | 0.0688 | 0.0780 | 0.0450 | 0.3586 |
| TGFB2 | 44 (16) | 21 (9) | 13 (4) | 0.1010 | 0.2550 | 0.0396 | 0.2298 |
| CCL2 | 12 (4) | 47 (8) | 32 (14) | 0.0114 | 0.1599 | 0.1440 | 0.0083 |
| CD68 | 43 (10) | 77 (9) | 86 (21) | 0.0304 | 0.3320 | 0.0818 | 0.0760 |
| integrin αE | 11 (5) | 28 (4) | 28 (6) | 0.0174 | 0.4679 | 0.0500 | 0.0083 |
| TLR3 | 13 (3) | 35 (5) | 29 (7) | 0.0141 | 0.2380 | 0.0674 | 0.4101 |
Bold, p value < 0.05
Underline, RNA also downregulated significantly in LN