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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Biotechnol Bioeng. 2014 Aug 5;111(11):2317–2325. doi: 10.1002/bit.25289

Table III.

Pharmacokinetic parameters of plasma clearance of IDS enzyme activity at week 25

parameter units Infusion dose (mg/kg)
3 10 30
Cmax units/mL 8,046 ± 3,474 30,789 ± 11,370 182,077 ± 28,943
T1/2 min 25.3 ± 2.4 29.8 ± 1.8 34.5 ± 4.2
MRT min 36.5 ± 3.5 43.0 ± 2.7 49.8 ± 6.2
AUC kunits•min/ml 320 ± 26 1,397 ± 74 8,374 ± 811
Vss mL/kg 84.0 ± 7.2 75.8 ± 4.2 43.9 ± 4.4
CL mL/min/kg 2.301 ± 0.191 1.760 ± 0.091 0.881 ± 0.085
ID kunits 4,043 ± 643 14,018 ± 1,776 40,393 ± 4,829
BW kg 5.48 ± 0.87 5.70 ± 0.72 5.47 ± 0.65

Mean ± SD. Parameters determined by fitting mono-exponential function to plasma IDS enzyme activity given in Figure 5; kunits = kilounits.