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. Author manuscript; available in PMC: 2014 Sep 27.
Published in final edited form as: Sci Transl Med. 2014 Mar 26;6(229):229ra43. doi: 10.1126/scitranslmed.3007965

Figure 5. Paclitaxel causes multipolar spindles in patient tumors.

Figure 5

(A) Immunofluorescence of patient tumors reveals additional spindle poles, indicated by NuMA staining. Not all poles contain γ-tubulin. Asterisks denote misaligned chromosomes, which occur even on bipolar spindles. Scale bar = 2.5 μm. (B) The incidence of multipolar spindles, defined as containing >2 NuMA foci, increased in every patient after paclitaxel treatment. Samples sizes for patients 1, 3, 4, 5 and 6, respectively, are 9, 9, 25, 53, and 19 mitotic cells pre-treatment and 11, 31, 29, 35 and 26 mitotic cells post-paclitaxel.