Table 2.
Univariate exact logistic regression results for association of odds of a renal event and selected baseline characteristics
| Variable | All Renal Events | All Renal Events leading to Treatment change | ||||||
|---|---|---|---|---|---|---|---|---|
| Odds Ratio (OR) | 95% Confidence Interval for OR | p-value | OR | 95% Confidence Interval for OR | p-value | |||
| Randomized Treatment – LPV/r versus NVP | 3.09 | 1.21 | 7.88 | 0.018 | 2.23 | 0.77 | 6.48 | 0.14 |
| Prior Single Dose NVP Exposure– No versus Yes | 1.88 | 0.69 | 5.09 | 0.22 | 2.13 | 0.60 | 7.55 | 0.24 |
| Age, per 10 years higher | 1.97 | 1.18 | 3.32 | 0.010 | 2.57 | 1.39 | 4.75 | 0.003 |
| Weight, per 10 kg higher | 0.72 | 0.48 | 1.08 | 0.11 | 0.68 | 0.41 | 1.13 | 0.13 |
| Height, per 10 cm higher | 1.42 | 0.73 | 2.77 | 0.30 | 0.71 | 0.31 | 1.61 | 0.41 |
| BMI, per kg/m2 higher | 0.91 | 0.81 | 1.01 | 0.078 | 0.94 | 0.83 | 1.06 | 0.31 |
| HIV-1 RNA, per 1 log10 copies/mL higher | 2.68 | 1.28 | 5.64 | 0.009 | 4.14 | 1.64 | 10.47 | 0.003 |
| Hemoglobin, per 1 g/dL higher | 0.79 | 0.62 | 1.00 | 0.054 | 0.73 | 0.54 | 0.98 | 0.033 |
| Creatinine Clearance, per 10 mL/min higher | 0.80 | 0.68 | 0.94 | 0.008 | 0.75 | 0.61 | 0.93 | 0.008 |
| CD4 count, per 100 cells/mm3 higher | 0.39 | 0.19 | 0.83 | 0.014 | 0.33 | 0.13 | 0.83 | 0.018 |
LPV/r: lopinavir/ritonavir; NVP: nevirapine; BMI: body mass index