Methods | Parallel trial. Randomization concealed using sealed opaque envelopes. Random list generated using random permuted blocks. Unblinded. |
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Participants | People with newly diagnosed epilepsy. Number randomized = PHB group = 58 people, PHT group = 63 people. 44% of participants had partial epilepsy. 49% of participants were male. Mean age (range) 34 (14-77) years. Follow-up in months: median (range) 61 (1-156). |
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Interventions | Monotherapy with PHB or PHT. Median daily dose achieved PHB = 105 mg/day PHT = 300 mg/day. |
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Outcomes | Time to 12-month remission. Time to first seizure. |
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Notes | ||
Risk of bias | ||
Item | Authors’ judgement | Description |
Allocation concealment? | Yes | A - Adequate |