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. Author manuscript; available in PMC: 2014 Sep 27.
Published in final edited form as: Cochrane Database Syst Rev. 2003 Apr 22;(2):CD002217. doi: 10.1002/14651858.CD002217
Methods Parallel trial.
Randomization concealed using sealed opaque envelopes.
Random list generated using random permuted blocks.
Unblinded.
Participants People with newly diagnosed epilepsy.
Number randomized = PHB group = 58 people, PHT group = 63 people.
44% of participants had partial epilepsy.
49% of participants were male.
Mean age (range) 34 (14-77) years.
Follow-up in months: median (range) 61 (1-156).
Interventions Monotherapy with PHB or PHT.
Median daily dose achieved
PHB = 105 mg/day
PHT = 300 mg/day.
Outcomes Time to 12-month remission.
Time to first seizure.
Notes
Risk of bias
Item Authors’ judgement Description
Allocation concealment? Yes A - Adequate