Fig. 4.
Internal concentrations of Al2O3-NP over various exposure concentrations as obtained by LA-ICP-MS measurements after 24 h of exposure. Results are presented for each particle type and cell line in one diagram. Data are shown as mean ± standard deviation of at least three independent replicates. The obtained LA-ICP-MS values are converted into the internalized particle mass by external calibration using individually spiked agarose gels. Significant differences between the cell lines were tested with two-way ANOVA (**p < 0.01)