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. 2013 Nov 20;13:117. doi: 10.1186/1475-2867-13-117

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Copyright © 2013 Chang et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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CD44 suppression inhibited nuclear translocation of β-catenin. (A) Decreased β-catenin mRNA expression after CD44shRNA transfection. (B) The protein expressions of β-catenin and p-β-catenin. (C/D) The relative protein expression of β-catenin and p-β-catenin compared to GAPDH. *, P < 0.05, **, P < 0.01, compared with the control. (E) Confocal laser microscope showing the decreased nuclear translocation of β-catenin after treatment with CD44shRNA. The green panel is GFP; the red panel isβ-catenin and the blue panel is cell nuclear.