Table 1.
Plasma inflammatory cytokines and adipokines in HFD and db/db mice treated with corresponding interventions
|
HFD mice | |||||
| |
CT |
PHZ |
ViL |
VaL |
ViLVaL |
| CRP (ng/mL) |
51.6 ± 6.1 |
46.1 ± 4.0 (0.18) |
39.7 ± 3.4* (0.027) |
44.0 ± 4.9* (0.043) |
35.9 ± 2.2** (0.0042) |
| TNF-α (pg/mL) |
12.9 ± 1.6 |
12.7 ± 1.5 (0.53) |
10.9 ± 0.7* (0.023) |
10.0 ± 0.6* (0.029) |
9.0 ± 0.6* (0.011) |
| IL-6 (pg/mL) |
11.1 ± 1.1 |
10.8 ± 1.0 (0.13) |
9.8 ± 0.6 (0.09) |
10.8 ± 0.5 (0.07) |
8.7 ± 0.5* (0.032) |
| MCP-1 (pg/mL) |
76.4 ± 7.3 |
73.5 ± 5.6 (0.21) |
67.8 ± 4.5 (0.64) |
59.4 ± 5.0* (0.033) |
45.7 ± 3.6** † (0.003) |
| Leptin (ng/mL) |
15.6 ± 1.1 |
15.3 ± 1.0 (0.32) |
15.0 ± 0.9 (0.53) |
15.1 ± 0.5 (0.074) |
15.0 ± 0.09 (0.09) |
| Adiponectin (μg/dL) |
8.7 ± 0.9 |
8.4 ± 0.7 (0.28) |
9.8 ± 0.5* (0.031) |
8.8 ± 0.6 (0.09) |
10.8 ± 0.5** (0.004) |
|
db/db mice | |||||
| |
CT |
PHZ |
ViL |
VaL |
ViLVaL |
| CRP (ng/mL) |
70.1 ± 4.1 |
55.1 ± 2.3* (0.039) |
46.4 ± 3.9* (0.012) |
53.3 ± 4.9* (0.024) |
38.5 ± 3.6** (0.007) |
| TNF-α (pg/mL) |
18.6 ± 1.0 |
15.6 ± 1.6 (0.24) |
11.8 ± 0.7** (0.002) |
10.1 ± 0.5** (0.0042) |
10.2 ± 0.5** (0.0002) |
| IL-6 (pg/mL) |
17.1 ± 0.9 |
14.3 ± 0.8 (0.11) |
13.2 ± 0.8* (0.045) |
12.1 ± 0.8* (0.043) |
11.9 ± 0.8* (0.039) |
| MCP-1 (pg/mL) |
118.7 ± 8.6 |
105.6 ± 7.3 (0.43) |
73.5 ± 3.9** (0.0002) |
68.2 ± 5.6** (0.003) |
56.4 ± 3.1** (0.0005) |
| Leptin (ng/mL) |
23.2 ± 1.4 |
22.6 ± 1.1 (0.18) |
22.1 ± 1.1 (0.26) |
23.5 ± 0.7 (0.31) |
23.1 ± 0.7 (0.85) |
| Adiponectin (μg/dL) | 6.1 ± 0.6 | 7.2 ± 0.5 (0.07) | 7.7 ± 0.5* (0.0015) | 6.9 ± 0.4 (0.078) | 7.15 ± 0.5* (0.0043) |
Values represent mean ± SEM, n = 12 – 14.
*p < 0.05, **p < 0.01 compared with the CT group. †p < 0.05 compared with the ViL group.
The numbers in parenthesis indicate p values.