Table 1.

Phenotype Groups and Sample Selection Strategies

Phenotype Group	Strategy	Targeted Number of Extreme Participants^*
Phenotype Group	Strategy	FHS	CHS	ARIC
EKG PR interval	High residual^†	50	50	100
EKG QRS interval	High	50	50	100
Stroke	Ischemic stroke	50	70	80
Blood Pressure	Low residual^†	25	25	54
Blood Pressure	High residual^†	25	25	46
Body Mass Index	High residual^†	50	50	100
Fasting Insulin	High	50	50	100
Bone mineral density by DEXA	Low z-score	100	100	-
Left ventricular diastolic diameter	High residual^†	100	100	-
C-reactive protein	High residual^†	50	50	100
Hematocrit	Low residual^†	50	50	100
Retinal venule diameter	High residual^†	-	34	166
Carotid wall thickness	High	50	50	100
Pulmonary: FEV1/FVC	Low	-	-	200
Atrial Fibrillation	Lone atrial	-	-	-
Atrial Fibrillation	fibrillation^‡	-	-	-

These numbers represent the number of participants with extreme phenotypes targeted for selection by each Phenotype Group, but do not reflect the additional participants who may have met the criteria for an extreme phenotype but had already been selected by other Phenotype Groups or as part of the Cohort Random Sample

^†

Extreme samples were selected by taking either the extreme high or low distribution based on age, sex, and phenotype specific variable adjusted residuals

^‡

200 cases with lone atrial fibrillation were selected from Massachusetts General Hospital