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. 2014 Aug 28;13:125. doi: 10.1186/s12934-014-0125-0

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© Fitzgerald and Glick; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Predicted structures of domains 1 and 2 of Vps10 compared to the known structure of sortilin. The protein sequences of S. cerevisiae Vps10 domain 1 (residues 22–737) and domain 2 (residues 719–1393) were submitted to the protein homology/analogy recognition engine Phyre (http://www.sbg.bio.ic.ac.uk/phyre/html/) [54], which detected the similarity to sortilin and generated PDB files for the predicted tertiary structures. A file for the experimentally determined structure of the human sortilin lumenal domain (PDB ID 3F6K) [53] was downloaded from the National Center for Biotechnology Information. To generate the images shown, these PDB files were opened with MacPyMOL using the default settings.