Figure 4. ADAM10 mediated Notch signaling is required for cell lineage specification and progenitor cell proliferation.
(A), Immunofluorescence analysis of cell lineage markers in the newborn small intestine from Vil-Cre;Adam10f/f and in different Notch mutants. (B), Quantification of Ki67+ cells per field (n=3–4). p values of group comparisons between Adam10f/f and other genotypes are shown. *p<0.05, **p<0.01, ****p<0.0001. Scale bars (μm) = 100.