Table 3.

AEs of CQ and PQ in the four groups.

PQ regimens	Group A (no PQ)	Group B (15 mg/day × 14 days)	Group C (30 mg/day × 7 days)	Group D (30 mg/day × 14 days)
Number of patients enrolled	397	398	381	380
AEs of CQ∗	1	0	4	4
Drop outs (discontinuation of CQ) due to CQ AEs	0	0	0	1
AEs of PQ∗∗	3	5	10	13
Drop outs (discontinuation of PQ) due to PQ AEs∗∗∗	0	2	2	7
Total drop outs due to AEs (CQ and PQ)∗∗∗∗	None	2	2	8

*P = 0.033, **P = 0.006, ***P = 0.003, ****P = 0.001.