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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Mol Cell Endocrinol. 2014 Aug 1;395(0):19–31. doi: 10.1016/j.mce.2014.07.020

Fig. 6.

Fig. 6

HDAC3 co-represses STAT5b on Socs2, Cish and Bcl6. Plasmids for Socs2-luc (top), Cish-luc (middle) or Bcl6-luc (bottom) were transfected into 293T cells in the absence (bars 1–2) or presence of BCL6 (bars 3–4), or constitutively active STAT5b (CA-STAT5b) (bars 5–6). Plasmid for HDAC3 (gray bars 2, 4, 6) or empty vector (pcDNA3, open bars 1, 3, 5) was co-expressed as indicated. Bars represent means + SE for 5 (Socs2, Cish) or 6 (Bcl6) independent experiments. Asterisks (*) indicate that BCL6 significantly (P < 0.05) repressed expression compared to basal luciferase (bar 1). Hatch signs (#) show responses to HDAC3 that are significantly (P < 0.05) lower than respective pair in the absence of HDAC3.