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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Trends Endocrinol Metab. 2013 Oct 18;25(1):42–52. doi: 10.1016/j.tem.2013.09.002

Figure 4. HDAC regulation of longevity pathways.

Figure 4

HDACs deacetylate both histone and non-histone proteins, regulating gene transcription and the post-translational function of proteins. HDACs regulate a variety of pathways implicated in longevity and age-related disease, and modulation of HDAC activity regulates lifespan in model organisms.