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. 2014 Sep 24;9(9):e108174. doi: 10.1371/journal.pone.0108174

Figure 5. Bort pretreatment increases pup number per litter and ovarian weight following DXR.

Figure 5

Number of pups birthed in each litter were counted and weighed for each treatment group. A. Plot depicts the mean number of pups per litter (± SE) for each litter number for each dam treatment group. Linear fit for Bort-DXR has a slope of 0.35±0.06 SE, DXR linear slope  = −0.31±0.04. *p = 0.033 for DXR vs. Bort-DXR, two-way ANOVA. Only 1 DXR-treated mouse achieved a sixth litter; the point is not plotted as no error can be calculated. B. Graph plots mean weight of ovary (mg) ± SE for each treatment group at 8 months of age [ctl = 10.4±0.4 mg (n = 36), DXR = 7.6±1.2 mg (n = 8), Bort-DXR = 9.1±0.7 mg (n = 22), Bort = 11.3±0.7 mg (n = 32)]. DXR induced a significant reduction in ovary weight (p<0.05, one-way ANOVA). Bort-DXR and Bort treatment groups were not significantly different from control.