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. 2013 Dec 4;18(1):52. doi: 10.1186/2047-783X-18-52

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Copyright © 2013 Lv et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Cells were cultured in Transwell chambers with the upper part coated with laminin (LN) or fibronectin (FN) respectively for 48 hours. The invaded cells were numerated under a light microscope (×400). (A) HepG2 infected by control shRNA plasmids invaded LN. (B) HepG2 cells infected by control shRNA plasmids invaded FN. (C) HepG2 cells infected by integrin α6 shRNA plasmids invaded LN. HepG2 had a decreased invasion potential after the knockdown of integrin α6 with significant statistical difference (P < 0.0001). It also proved that LN can increase invasion potential of HepG2 (P < 0.05).