Table 1.
Genotype distributions of SNX24 gene SNPs in Taiwanese KD patients and controls
|
SNP |
Chromosome |
Cytoband |
Physical position |
Nearest genes |
|
Controls |
KD patients |
||
|---|---|---|---|---|---|---|---|---|---|
| No. (%) | No. (%) | p value | Odds ratio (95% CI) | ||||||
| rs154507 |
5 |
q23.2 |
122228806 |
SNX24 |
GG |
146 (13.2) |
38 (14.5) |
0.755 |
1.17 (0.76–1.78) |
| |
|
|
|
|
GC |
553 (50.0) |
133 (50.8) |
|
1.08 (0.80–1.45) |
| |
|
|
|
|
CC |
408 (36.8) |
91 (34.7) |
|
1 |
| rs27740 |
5 |
q23.2 |
122232671 |
SNX24 |
TT |
156 (14.1) |
38 (14.5) |
0.867 |
1.08 (0.71–1.65) |
| |
|
|
|
|
TA |
547 (49.4) |
133 (50.8) |
|
1.08 (0.80–1.45) |
| |
|
|
|
|
AA |
404 (36.5) |
91 (34.7) |
|
1 |
| rs26371 |
5 |
q23.2 |
122234424 |
SNX24 |
TT |
217 (19.6) |
56 (21.4) |
0.690 |
1.19 (0.80–1.76) |
| |
|
|
|
|
TC |
573 (51.8) |
137 (52.3) |
|
1.10 (0.80–1.51) |
| |
|
|
|
|
CC |
317 (28.7) |
69 (26.3) |
|
1 |
| rs6595415 |
5 |
q23.2 |
122234657 |
SNX24 |
TT |
151 (13.6) |
38 (14.5) |
0.842 |
1.12 (0.73–1.70) |
| |
|
|
|
|
TC |
530 (47.9) |
128 (48.9) |
|
1.07 (0.80–1.44) |
| |
|
|
|
|
CC |
426 (38.5) |
96 (36.6) |
|
1 |
| rs17149732 |
5 |
q23.2 |
122249811 |
SNX24 |
TT |
146 (13.2) |
37 (14.1) |
0.784 |
1.14 (0.74–1.73) |
| |
|
|
|
|
TG |
530 (47.9) |
129 (49.2) |
|
1.09 (0.81–1.46) |
| |
|
|
|
|
GG |
430 (38.9) |
96 (36.6) |
|
1 |
| rs17149748 |
5 |
q23.2 |
122295266 |
SNX24 |
CC |
150 (13.6) |
37 (14.1) |
0.710 |
1.13 (0.74–1.72) |
| |
|
|
|
|
CT |
532 (48.1) |
131 (50.0) |
|
1.13 (0.84–1.51) |
| |
|
|
|
|
TT |
425 (38.4) |
93 (35.5) |
|
1 |
| rs1038078 |
5 |
q23.2 |
122309550 |
SNX24 |
AA |
147 (13.3) |
37 (14.1) |
0.676 |
1.15 (0.75–1.76) |
| |
|
|
|
|
AG |
526 (47.5) |
130 (49.6) |
|
1.13 (0.84–1.51) |
| |
|
|
|
|
GG |
434 (39.2) |
95 (36.3) |
|
1 |
| rs28891 |
5 |
q23.2 |
122311523 |
SNX24 |
CC |
187 (16.9) |
47 (17.9) |
0.836 |
1.12 (0.75–1.67) |
| |
|
|
|
|
CT |
554 (50.1) |
133 (50.8) |
|
1.07 (0.79–1.45) |
| |
|
|
|
|
TT |
366 (33.1) |
82 (31.3) |
|
1 |
| rs6595423 |
5 |
q23.2 |
122341433 |
SNX24 |
CC |
144 (13.0) |
36 (13.7) |
0.667 |
1.14 (0.75–1.75) |
| |
|
|
|
|
CT |
524 (47.3) |
130 (49.6) |
|
1.13 (0.85–1.52) |
| TT | 439 (39.7) | 96 (36.6) | 1 | ||||||
SNX24, sorting nexin 24; SNP, single nucleotide polymorphism; CI, confidence interval.
p-values were obtained by chi-square test.
Bold, emphasizing statistical significance was considered as p value <0.006 (0.05/9).