Table 2.
Summary of the SNPs associated with the CAA formation in Taiwanese Kawasaki disease
|
SNP |
Chromosome |
Cytoband |
Physical position |
Nearest genes |
|
CAA- |
CAA+ |
|
|
|---|---|---|---|---|---|---|---|---|---|
| No. (%) | No. (%) | p value | Odds ratio (95% CI) | ||||||
| rs154507 |
5 |
q23.2 |
122228806 |
SNX24 |
GG |
24 (12.9) |
14 (18.4) |
0.234 |
1.94 (0.86–4.41) |
| |
|
|
|
|
GC |
92 (49.5) |
41 (54.0) |
|
1.49 (0.81–2.74) |
| |
|
|
|
|
CC |
70 (37.6) |
21 (27.6) |
|
1 |
| rs27740 |
5 |
q23.2 |
122232671 |
SNX24 |
TT |
24 (12.9) |
14 (18.4) |
0.234 |
1.94 (0.86–4.41) |
| |
|
|
|
|
TA |
92 (49.5) |
41 (54.0) |
|
1.49 (0.81–2.74) |
| |
|
|
|
|
AA |
70 (37.6) |
21 (27.6) |
|
1 |
| rs26371 |
5 |
q23.2 |
122234424 |
SNX24 |
TT |
44 (23.7) |
12 (15.8) |
0.123 |
0.45 (0.20–1.01) |
| |
|
|
|
|
TC |
99 (53.2) |
38 (50.0) |
|
0.63 (0.34–1.17) |
| |
|
|
|
|
CC |
43 (23.1) |
26 (34.2) |
|
1 |
| rs6595415 |
5 |
q23.2 |
122234657 |
SNX24 |
TT |
23 (12.4) |
15 (19.7) |
0.198 |
2.07 (0.93–4.61) |
| |
|
|
|
|
TC |
90 (48.4) |
38 (50.0) |
|
1.34 (0.73–2.45) |
| |
|
|
|
|
CC |
73 (39.2) |
23 (30.3) |
|
1 |
| rs17149732 |
5 |
q23.2 |
122249811 |
SNX24 |
TT |
23 (12.4) |
14 (18.4) |
0.261 |
1.93 (0.86–4.36) |
| |
|
|
|
|
TG |
90 (48.4) |
39 (51.3) |
|
1.38 (0.75–2.51) |
| |
|
|
|
|
GG |
73 (39.2) |
23 (30.3) |
|
1 |
| rs17149748 |
5 |
q23.2 |
122295266 |
SNX24 |
CC |
23 (12.4) |
14 (18.4) |
0.242 |
1.96 (0.87–4.45) |
| |
|
|
|
|
CT |
91 (49.2) |
40 (52.6) |
|
1.42 (0.77–2.60) |
| |
|
|
|
|
TT |
71 (38.4) |
22 (29.0) |
|
1 |
| rs1038078 |
5 |
q23.2 |
122309550 |
SNX24 |
AA |
23 (12.4) |
14 (18.4) |
0.283 |
1.91 (0.84–4.30) |
| |
|
|
|
|
AG |
91 (48.9) |
39 (51.3) |
|
1.34 (0.74–2.45) |
| |
|
|
|
|
GG |
72 (38.7) |
23 (30.3) |
|
1 |
| rs28891 |
5 |
q23.2 |
122311523 |
SNX24 |
CC |
39 (21.0) |
8 (10.6) |
0.006
|
0.29 (0.12–0.70) |
| |
|
|
|
|
CT |
99 (53.2) |
34 (44.7) |
|
0.48 (0.27–0.87) |
| |
|
|
|
|
TT |
48 (25.8) |
34 (44.7) |
|
1 |
| rs6595423 |
5 |
q23.2 |
122341433 |
SNX24 |
CC |
23 (12.4) |
13 (17.1) |
0.322 |
1.79 (0.79–4.10) |
| |
|
|
|
|
CT |
90 (48.4) |
40 (52.6) |
|
1.41 (0.78–2.57) |
| TT | 73 (39.2) | 23 (30.3) | 1 |
SNX24, sorting nexin 24; SNP, single nucleotide polymorphism; CAA, Coronary artery aneurysm; CI, confidence interval.
p-values were obtained by chi-square test.
Bold, emphasizing statistical significance was considered as p value <0.05.