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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Biol Psychiatry. 2014 Mar 26;77(5):445–453. doi: 10.1016/j.biopsych.2014.03.020

Figure 3.

Figure 3

Effect of decreased MD activity on instrumental contingency degradation. A, Schematic drawing of the experiment design. Abbreviations: Lever-press response (R), outcome (milk) (O). [p(O/R)=0.05]: probability of obtaining outcome after lever press is 5%. [p(O/no R)=0]: probability of obtaining outcome meanwhile no pressing is 0% B, Mean lever press performed per minute (±SEM) during 20 minutes instrumental training session. C, Mean lever presses (in percentage from baseline) (±SEM) across the contingency degradation sessions. Left panel: control groups. Right panel: pooled controls vs CNO-treated MDhM4D mice (GFP-Sal n=8, GFP-CNO n=7, hM4D-Sal n=15, hM4D-CNO n=14).