. Author manuscript; available in PMC: 2015 Dec 1.

Published in final edited form as: Toxicol Pathol. 2014 Mar 26;42(8):1188–1196. doi: 10.1177/0192623314525688

Table 1.

Mean ± SD Peak Plasma Concentrations of Tamoxifen Metabolites in Rats after Oral Dosing of Tamoxifen and Endoxifen Once Daily for Three Days (n=5)

Drug	Dose (mg/kg)	Tamoxifen (nM)	Endoxifen (nM)	4-OH-Tamoxifen (nM)	N-Desmethyl-Tamoxifen (nM)
Tamoxifen^a	20	924 ± 111	69 ± 9	135 ± 18	682 ± 104
Tamoxifen^a	200	8380 ± 1530	129 ± 43	768 ± 106	4920 ± 730
Endoxifen*	5	---	168 ± 102	---	---
	80	---	8050 ± 1080	---	---
	200	---	9620 ± 1740	---	---

Tamoxifen, t = 2 hrs after dosing on Day 3; Endoxifen, t = 4 hrs after dosing on Day 3