Table 2.
Mean ± SEM Body and Organ Weights 24 Hours after Three Daily Treatments with Tamoxifen, Endoxifen or Estradiol in Ovariectomized Sprague-Dawley Rats
| Treatment | Body weight (g) | Uterine weight (g) |
|---|---|---|
| 17-(3-estradiol benzoate (0.05 mg/kg/day) | 301±5.5 | 0.96±0.15 |
| Vehicle control (Tween 80/PEG 400) | 256±4.9 | 0.30±0.03 |
| Tamoxifen (20 mg/kg/day) | 257±4.1 | 0.40±0.05 |
| Tamoxifen (200 mg/kg/day) | 248±12 | 0.34±0.08 |
| Vehicle control (water) | 283±10 | 0.33±0.10 |
| Endoxifen (5 mg/kg/day) | 257±3.4 | 0.28±0.04 |
| Endoxifen (80 mg/kg/day) | 249±4.8a | 0.25±0.01 |
| Endoxifen (200 mg/kg/day) | 244±4.9a | 0.26±0.03 |
a
Statistical significance compared to vehicle (water) control, P≤0.05