Table 1.
Clinicopathological features and the expression of nucleolin in 130 hepatocellular carcinoma patients
| Clinicopathological features | Case | Nucleolin expression frequency (n,%) | P | |
|---|---|---|---|---|
| High | Low | |||
| Age (years) | ||||
| ≤50 | 72 | 40 (55.56) | 32 (44.44) | NS |
| >50 | 58 | 28 (48.28) | 20 (51.72) | |
| Gender | ||||
| Male | 96 | 58 (60.42) | 42 (39.58) | NS |
| Female | 34 | 20 (58.82) | 14 (41.18) | |
| Serum AFP | ||||
| Positive | 72 | 58 (80.56) | 14 (19.44) | 0.008 |
| Negative | 58 | 20 (34.48) | 38 (65.52) | |
| Tumor stage | ||||
| T1 | 23 | 0 (0) | 23 (100.00) | 0.001 |
| T2 | 40 | 23 (57.50) | 17 (42.50) | |
| T3 | 52 | 40 (76.92) | 12 (23.08) | |
| T4 | 15 | 15 (100.00) | 0 (0) | |
| Tumor grade | ||||
| G1 | 31 | 12 (38.71) | 19 (61.29) | 0.02 |
| G2 | 76 | 48 (63.16) | 28 (36.84) | |
| G3 | 23 | 18 (78.26) | 5 (21.74) | |
| Growth pattern | ||||
| Trabecular | 101 | 59 (58.42) | 42 (41.58) | NS |
| Nontrabecular | 29 | 19 (65.52) | 10 (34.48) | |
| Cirrhosis | ||||
| Yes | 86 | 50 (58.14) | 36 (41.86) | NS |
| No | 44 | 28 (63.64) | 16 (36.46) | |
| Underlying liver disease | ||||
| Alcoholic | 25 | 10 (40.00) | 15 (60.00) | NS |
| Hepatitis B | 49 | 28 (57.14) | 21 (42.86) | |
| Hepatitis C | 35 | 28 (80.00) | 7 (20.00) | |
| Unknown | 21 | 12 (57.14) | 9 (42.86) | |
Note: ‘NS’ refers to the differences among groups have no statistical significance.