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. 2006 Nov 22;26(47):12165–12173. doi: 10.1523/JNEUROSCI.3576-06.2006

Figure 4.

Figure 4.

Activity in right and left DLPFC locations with peak atrophy in CBP (Apkarian et al., 2004b), during high pain, show an inverse relationship between mPFC but not with insula. A, Across-subject correlations between brain activity for right and left DLPFC locations with peak atrophy in CBP are negatively correlated with mPFC activity (p < 0.01), and uncorrelated to insula activity (p > 0.64), for periods when spontaneous pain is high. B, BOLD responses show early transient DLPFC activity, which become deactivated in the period in which mPFC activity increases. Across-subject mean and SEMs are shown. C, Brain regions and correlations are depicted on the brain. Note that these relations are only true during high pain phase. All four areas are significantly positively correlated with each other during increasing phase of spontaneous CBP.