Figure 6.

Pain intensity for spontaneous CBP and thermal pain are encoded in different brain regions. A, Pain intensity for spontaneous pain of CBP (mean rating of pain during scan) exhibits a significant positive correlation with mPFC activity (p < 0.001, replicating the result shown in Fig. 3A) and is uncorrelated with insular activity. B, Pain intensity for thermal pain in both CBP patients and normal subjects is best correlated with insular activity (p < 0.01) and shows no correlation with mPFC activity (x, y, and z coordinates in millimeters).