. Author manuscript; available in PMC: 2015 Oct 1.

Published in final edited form as: Ann Biomed Eng. 2014 Aug 1;42(10):2003–2013. doi: 10.1007/s10439-014-1071-z

TABLE 1.

Myofilament calcium response parameters

Parameter	Definition	Index of	Explanation
pCa₅₀	Calcium concentration required for half-maximal activation	Calcium sensitivity of force	Quantifies the amount calcium it takes to reach half-maximal force
n_H	Hill coefficient	Myofilament cooperativity of force development	Slope of the force-pCa curve; it is the result of increased receptor affinity for Ca²⁺ after a Ca²⁺ binds to the target troponin subunit
F_max	Maximal Ca²⁺ activated force	Maximal sarcomere generated force	Maximum sarcomere force generated by exposing myocytes to Ca²⁺ solutions
k_tr	Rate constant of force redevelopment	Myosin cross-bridge kinetics	Characterizes transitions from non-force generating to force generating states