Table 1.

Early stress increases the prevalence of spontaneous network activity in the presence of the 5-HT₂ receptor agonist DOI

	Control	Early stress	p value
Number of cells displaying network activity/total number of cells	2/13 (15%)	12/13 (92%)	0.0002
Amplitude (pA)	−17.4 ± 9.5	−67.9 ± 8.3	0.06
Duration (ms)	450 ± 50	651 ± 205	0.7

Voltage-clamp recordings (10 min per neuron) were made from control and ES neurons following application of DOI (3 μm; 15 min) to the brain slice. Under these conditions, activity patterns consistent with network activity (Sanchez-Vives and McCormick, 2000) were observed in very few neurons from control animals and in almost all neurons from ES animals (significance assessed with Fisher's exact test). The amplitude and duration of the measured network events in each group are shown as mean ± SEM (controls: 2 events; ES: 17 events) and were compared with Student's unpaired t test.