Table 6.
Multivariate analysis estimating risk of haemoglobin drop from baseline to ≥2 g/dL during different post-treatment follow-up visits
| Day 7 (2,657) | Day 14 (n=4,638) | Day 28 (n=4,082) | ||||
|---|---|---|---|---|---|---|
| OR* (95% CI) | p | OR*(95% CI) | p | OR* (95% CI) | p | |
| Covariates** | ||||||
| AL | 0.51 (0.28-0.90) | 0.02 | 1.33 (0.95-1.87) | 0.10 | 0.86 (0.54-1.39) | 0.55 |
| AS+partners | 0.70 (0.52-0.94) | 0.02 | 0.95 (0.69-1.32) | 0.78 | 0.96 (0.63-1.44) | 0.83 |
| AS | 1.36 (0.97-1.92) | 0.08 | 0.99 (0.61-1.59) | 0.96 | 1.07 (0.58-1.96) | 0.83 |
| <5 years old | 0.87 (0.68-1.11) | 0.25 | 0.82 (0.65-1.04) | 0.10 | 0.82 (0.60-1.12) | 0.21 |
| P.f. day 0 | 1.80 (1.41-2.30 | <0.001 | 1.68 (1.33-2.12) | <0.001 | 1.30 (0.96-.75) | 0.09 |
| Treat fail | 1.43 (0.88-2.32) | 0.15 | 1.63 (1.13-2.38) | 0.01 | 2.03 (1.44-2.87) | <0.001 |
Note: *OR is the odds ratio obtained from generalized linear and latent mixed model with binomial family using site as random effect;
**Covariates references were: CQ, AQ, SP for day 7 and CQ, AQ, SP and SP-AQ for day 14 and day 28 for treatment, the age ≥ 5 years old for the age group, the 28-day cured parasite outcome after treatment for the treatment failure (Treat fail) outcome, the baseline parasite density was log transformed and treated as continuous variable; AS + partners were: AS-AQ, AS-SP, AS-PYR for day 7, AS-AQ, AS-SP, AS-MEF for day 14 and AS-AQ, AS-SP, AS-PYR, AS-SMP and AS-MEF for day 28.