Table 4.
BRCA1 gene polymorphism in probands without BRCA1 and BRCA2 gene mutation as shown by sequencing
| Nucleotide | Amino acid swap | Exon/intron | Frequency |
|---|---|---|---|
| IVS8-58delT | NC | 7 | Wt/Wt 33 WT/delT 30 delT/delT 8 |
| 1186A/G | Gln356Arg | 11 | 6 |
| 2430T/C | Leu771Leu | 11 | T/T 33 T/C 30 C/C 8 |
| 2731 C/T | Pro871Leu | 11 | C/C 33 C/T 30 T/T 8 |
| 3367A/G | Lys1183Arg | 11 | A/A 33 A/G 30 G/G 8 |
| 4427T/C | Ser1436Ser | 13 | T/T 33 T/C 30 C/C 8 |
| 4956A/G | Ser1613Gly | 16 | A/A 33 A/G 30 G/G 8 |
| IVS18+66G/A | NC | 18 | G/G 33 G/A 30 A/A 8 |
| IVS20+60ins12 | NC | 20 | 2 |
NC - non-coding sequence; Wt - wild-type sequence