Table 8.
Breast cancer cases associated with 5972C/T or TT variants in comparison to the wild 5972C/C sequence
| Parameters | 5972C/T or TT | 5972C/C | OR | p-value | 95%CI | ||||
|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | ||||||
| Histological diagnosis | |||||||||
| ductal cancer (%) | 41 | 36 | 604 | 35 | 1.04 | 0.83 | 0.7-1.5 | ||
| lobular cancer (%) | 22 | 19 | 364 | 21 | 0.90 | 0.70 | 0.5-1.5 | ||
| DCIS + microinvasion | 22 | 19 | 121 | 7 | 3.18 | <0.0001 | 1.9-5.2 | ||
| medullar cancer (%) | 7 | 6 | 122 | 7 | 0.86 | 0.71 | 0.4-1.9 | ||
| tubular or tubulolobular cancer (%) | 3 | 3 | 104 | 6 | 0.42 | 0.13 | 0.1-1.3 | ||
| Other | 19 | 17 | 416 | 24 | 0.63 | 0.09 | 0.4-1.0 | ||
| multifocal cancer (%) | 19 | 30 | 211 | 23 | 1.47 | 0.17 | 0.8-2.6 | ||
| bilateral cancer (%) | 7 | 5 | 63 | 3 | 1.71 | 0.18 | 0.7-3.8 | ||
| ER + (%) | 50 | 67 | 583 | 62 | 1.24 | 0.40 | 0.7-2.0 | ||
| Positive family history | |||||||||
| all cases | 32 | 21 | 569 | 26 | 0.72 | 0.14 | 0.5-1.2 | ||
| cases diagnosed <40 years of age | 4 | 10 | 97 | 24 | 0.36 | 0.06 | 0.1-1.1 | ||
| X | X | X | p-value | 95%CI | |||||
| mean age at diagnosis (years) | 43.9 | 44.4 | 0.5 | 0.34 | -2 | ||||
| mean tumour size (cm) | 2.0 | 2.1 | 0.1 | 0.41 | -0.4 | ||||