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. Author manuscript; available in PMC: 2015 Oct 7.
Published in final edited form as: Vaccine. 2014 Aug 27;32(44):5824–5831. doi: 10.1016/j.vaccine.2014.08.030

Fig. 4. Improved efficacy of cross protection by M2e5x VLPs immunization after split vaccine.

Fig. 4

Groups of mice (N=4) that were immunized with split or split and additional M2e5x VLP were intranasally challenged with a lethal dose (5xLD50) of influenza viruses, A/Philippines/2/82 (H3N2) or rgH5N1, 6 weeks after M2e5x VLP boost immunization. (A) Average body weight changes after A/Philippines/2/82 virus challenge. (B) Survival rates after A/Philippines/2/82 virus challenge. (C) Average body weight changes after rgH5N1 virus challenge. (D) Survival rates after rgH5N1 virus challenge. Error bars indicate mean ± SEM. LD, lethal dose. P value indicates significant difference between groups of split or S-M2e5x immunization.