Skip to main content
. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Neurochem Int. 2014 Apr 3;0:9–16. doi: 10.1016/j.neuint.2014.03.013

Table 2.

NcRNAs in brain vascular EC biology and pathologies

NcRNAs Function Targets References
miR-101 mediates the HIV-1 Tat C-induced impairment of endothelial barrier integrity and subsequent BBB dysfunction in human brain microvascular endothelial cells. VE-cadherin Mishra et al., 2013
miR-125a significantly diminishes in isolated multiple sclerosis patient capillaries and functions as a key regulator of brain endothelial tightness and immune cell efflux. VE-cadherin, ZO-1 Reijerkerk et al., 2013
miR-155 Meg3 Negatively regulates BBB breakdown in CNS neuroinflammatory disorders such as MS and EAE.inhibits angiogenesis in mouse brains. Annexin-2, Claudin-1, DOCK-1, Syntenin-1 VEGF signaling pathway Lopez-Ramirez MA, 2014,Gordon et al., 2010 Zhou et al., 2012
HHS Vulnerability Disclosure