Table 3.

Stroke-Associated Cerebrovascular Endothelial Cell ncRNAs

NcRNAs	Functions	Targets	Cell types	References
miR-15a	Increases in ischemic brain vasculature. Gain- or loss-of-miR-15a function reduces or increases EC viability, tube formation, migration, and differentiation, respectively. EC-miR-15a transgenic overexpression leads to reduced blood vessel formation and local blood flow perfusion after hindlimb ischemia.	Bcl-2 FGF2, VEGF	CECs HUVECs	Yin et al., 2010b Yin et al., 2012
miR-100 et al., miR-139 et al.,	Nine miRNAs (miR-100, -101a, -204, - 210, m-224, -322, -322*, -331, -450a) are significantly upregulated in BMECs after stroke, whereas seven miRNAs (miR- 139-5p, -193*, -203, -225, -335, -494, -708) downregulated.	Unknown	BMECs	Teng et al.,2012
miR-210	Upregulates in rat ischemic brain cortexes. Overexpression increases Notch1 expression and induces ECs to migrate and form capillary-like structures on matrigel. Induces angiogenesis and neurogenesis in normal brain tissues.	Notch1 VEGF	HUVECs CECs Neurons Astrocytes	Lou et al., 2012 Zeng et al., 2013
miR-320	Downregulates in all young stroke patients with good outcome.	Unknown	Blood	Tan et al., 2009