Table 3.

Mutant CRX protein levels in alternate expression systems. The qualitative level of mutant CRX expression compared to WT CRX in either in vitro transient transfection of human retinal pigment epithelial-like cell (h-ARPE-19) or in vivo transgenic Drosophila otd^uvi rescue experiments.

Protein	cDNA	System	Expression level	Reference
p.I138d1	c.413del1	in vitro	overexpressed	Nichols et al. (2010)
p.I138d1	c.413del1	Drosophila in vivo rescue	overexpressed	Terrell et al. (2012)
p.K88N	c.264G>T	in vitro	normal	Nichols et al. (2010)
p.K88N	c.264G>T	Drosophila in vivo rescue	normal	Terrell et al. (2012)
p.E80A	c.239A>C	Drosophila in vivo rescue	normal	Terrell et al. (2012)
p.R90W	c.268C>T	Drosophila in vivo rescue	reduced	Terrell et al. (2012)