(A) Phylogenetic tree of KDM2 proteins in multicellular animals. This tree was built with MEGA 5 by pairwise algorithm and the Neighbor-Joining algorithm. The right side summarizes the presence (marked with a ‘+’) or absence (marked with a ‘−’) of the conserved domains, including JmjC, CXXC zinc finger, PHD, F-box and LRRs/Amn1 domains. The NCBI Reference Sequence number and the protein-protein BLAST (BLASTp) search results for the putative conserved domains for each KDM2 homolog are presented in the Fig. S1. (B) The domain organization of dKDM2, note that except a clear PHD domain, all the other four major domains are present in dKDM2.