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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Mech Dev. 2014 Jul 9;0:36–53. doi: 10.1016/j.mod.2014.06.003

Figure 1. Characterization of the conserved protein domains in KDM2 homologs.

Figure 1

(A) Phylogenetic tree of KDM2 proteins in multicellular animals. This tree was built with MEGA 5 by pairwise algorithm and the Neighbor-Joining algorithm. The right side summarizes the presence (marked with a ‘+’) or absence (marked with a ‘−’) of the conserved domains, including JmjC, CXXC zinc finger, PHD, F-box and LRRs/Amn1 domains. The NCBI Reference Sequence number and the protein-protein BLAST (BLASTp) search results for the putative conserved domains for each KDM2 homolog are presented in the Fig. S1. (B) The domain organization of dKDM2, note that except a clear PHD domain, all the other four major domains are present in dKDM2.