Table III.
Neonatal Pharmacokinetic Parameter Estimates
| ID† | GA (wks) |
Weight (gm) |
NAC dose (mg) |
t1/2 (hrs) |
Vd (L/kg) |
CL (mL/hr/kg) |
NAC Cord Cp* μmol/L |
NAC @ SS(48hrs)## μmol/L |
|---|---|---|---|---|---|---|---|---|
| 1-B-P | 29.3 | 1450 | 18.1 | 10.7 | 0.52 | 33.6 | NA∞ | 68.0 |
| 2a-B-P | 27.6 | 1095 | 13.7 | 8.2 | 0.47 | 39.6 | 369.5 | 83.9 |
| 2b-B-P | 27.6 | 1090 | 13.6 | 6.9 | 0.47 | 47.2 | 357.8 | 60.7 |
| 3-B-P | 28.0 | 1310 | NA | NA | NA | NA | 465.0** | NA** |
| 4-B-P | 26.0 | 900 | 12.5 | 6.0 | 0.45 | 52.0 | 107.2†† | 60.0 |
| 5-B-P | 31.5 | 1550 | 19.4 | 5.6 | 0.42 | 51.9 | 235.3 | 57.6 |
| 6-B-P | 27.0 | 1055 | 13.2 | 6.0 | 0.48 | 52.6 | 689.3 | 66.8 |
| P Mean (SD) | 28.1(1.8) | 1207(235) | 7.5(2.0) | 0.47(0.04) | 45.0(8.2) | 370.7(199.2) | 66.2(9.5) | |
| 7-B-T | 38.3 | 3326 | 83.2 | 5.3 | 0.39 | 50.7 | 1183.7 | 63.1 |
| 8-B-T | 40.2 | 3940 | 98.5 | 4.0 | 0.30 | 52.2 | 586.4 | NA∞ |
| 9-B-T | 40.1 | 3705 | 92.6 | 5.9 | 0.53 | 62.0 | 598.6 | 102.9 |
| 10-B-T | 34.6 | 2842 | 45.0 | 3.9 | 0.38 | 73.0 | NA∞ | 49.0 |
| 11-B-T | 40.0 | 3440 | 85.0 | 3.5 | 0.34 | 66.3 | 189.9‡ | 29.4 |
| T Mean(SD) P |
39(2.4) <0.0001# |
3451(415) <0.0001# |
5.1(1.3) 0.02# |
0.38(0.09) .096 |
53.7(11.3) 0.021# |
639.7(409.4) 0.20 |
61.2(31.1) 0.71 |
†
P, preterm; T, term
*
NAC venous cord concentration at delivery
∞
Missed NAC sample collection
**
Withdrawn due to IVH
††
Delivered 9 min into NAC infusion
‡
Mother received ½ of second NAC dose
#
P vs. T Student t-test
##
Estimated NAC trough concentration at steady-state