Table IV.
Maternal and Neonatal NAC PK estimates
| ID† Maternal |
Weight (kg) |
t1/2 (hrs) |
Vd (L/kg) |
CL (mL/hr/kg) |
|---|---|---|---|---|
| 1-M-P | 129.0 | NA | NA | NA†† |
| 2-M-P | 108.0 | 1.1 | 0.43 | 264 |
| 3-M-P | 63.0 | 1.1 | 0.54 | 331 |
| 4-M-P | 95.0 | NA | NA | NA* |
| 5-M-P | 106.5 | 1.7 | 0.49 | 198 |
| 6-M-P | 87.3 | 0.9 | 0.39 | 290 |
| P:Mean (SD) | 98.1(22.2) | 1.2(0.31) | 0.46(0.07) | 271(56) |
| 7-M-T | 73.2 | NA | NA | NA‡ |
| 8-M-T | 84.0 | 1.1 | 0.39 | 256 |
| 9-M-T | 89.1 | 1.2 | 0.34 | 193 |
| 10-M-T | 90.5 | 0.8 | 0.38 | 331 |
| 11-M-T | 149.1 | 1.4 | 0.34 | 175 |
| T:Mean (SD) P+T Mean (SD) P value |
97(30) 98(25) 0.95 |
1.1(0.2) 1.2(0.2) 0.60 |
0.36(0.03) 0.41(0.07) 0.03‡‡ |
239(71) 255(61) 0.53 |
| ID Neonate |
Weight (gm) |
t1/2 (hrs) |
Vd (L/kg) |
CL (mL/hr/kg) |
| 1-B-P | 1450 | 10.7 | 0.52 | 33.6 |
| 2a-B-P | 1095 | 8.2 | 0.47 | 39.6 |
| 2b-B-P | 1090 | 6.9 | 0.47 | 47.2 |
| 3-B-P | 1310 | NA | NA | NA** |
| 4-B-P | 900 | 6.0 | 0.45 | 52.0 |
| 5-B-P | 1550 | 5.6 | 0.42 | 51.9 |
| 6-B-P | 1055 | 6.0 | 0.48 | 52.6 |
| P: Mean (SD) | 1207(235) | 7.5(2.0) | 0.47(0.04) | 45.0(8.2) |
| 7-B-T | 3326 | 5.3 | 0.39 | 50.7 |
| 8-B-T | 3940 | 4.0 | 0.30 | 52.2 |
| 9-B-T | 3705 | 5.9 | 0.53 | 62.0 |
| 10-B-T | 2842 | 3.9 | 0.38 | 73.0 |
| 11-B-T | 3440 | 3.5 | 0.34 | 66.3 |
| T Mean(SD) P |
3451(415) <0.0001‡‡ |
5.1(1.3) 0.02‡‡ |
0.38(0.09) .096 |
53.7(11.3) 0.021‡‡ |
†
M, maternal; P, preterm; T, term
††
Delivered 40 minutes into NAC infusion
*
Delivered 9 minutes into NAC infusion
‡
Stopped collecting NAC samples at delivery
‡‡
P vs. T Student t-test
**
Withdrawn due to IVH