Table 3.
Hazard ratios for RA phenotypes (all, seropositive, and seronegative) according to familial RA or lupus by affected first-degree relative (FDR) in age-adjusted models for women in the Nurses’ Health Study (n = 65,457).
| All RA (n = 493) |
Seropositive RA (n = 301) |
Seronegative RA (n = 192) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
|
Familial RA or lupus |
RA cases |
HR | 95% CI | RA cases |
HR | 95% CI | RA cases |
HR | 95% CI |
| No FDR | 350 | 1.0 | Ref | 215 | 1.0 | Ref | 135 | 1.0 | Ref |
| Parent | 95 | 4.27 | 3.39–5.37 | 61 | 5.08 | 3.80–6.78 | 34 | 4.23 | 2.89–6.19 |
| No FDR | 350 | 1.0 | Ref | 215 | 1.0 | Ref | 135 | 1.0 | Ref |
| Sibling | 46 | 3.35 | 2.45–4.58 | 25 | 3.10 | 1.03–4.73 | 21 | 4.19 | 2.62–6.70 |
| No FDR | 350 | 1.0 | Ref | 215 | 1.0 | Ref | 135 | 1.0 | Ref |
| Offspring | 27 | 4.12 | 2.76–6.14 | 14 | 3.65 | 2.11–6.33 | 13 | 5.19 | 2.90–9.28 |
| No FDR | 350 | 1.0 | Ref | 215 | 1.0 | Ref | 135 | 1.0 | Ref |
| Any FDR | 143 | 3.67 | 3.01–4.47 | 86 | 3.90 | 3.03–5.03 | 57 | 3.95 | 2.88–5.40 |
| No FDR | 350 | 1.0 | Ref | 215 | 1.0 | Ref | 135 | 1.0 | Ref |
| 1 FDR | 120 | 3.37 | 2.73–4.16 | 73 | 3.60 | 2.75–4.71 | 47 | 3.53 | 2.52–4.94 |
| ≥2 FDRs | 23 | 6.83 | 4.43–10.53 | 13 | 7.62 | 4.26–13.64 | 10 | 8.69 | 4.50–16.79 |
All models were adjusted for age and questionnaire period.
CI= confidence interval; FDR = first-degree relative; HR = hazard ratio; RA = rheumatoid arthritis; Ref = reference.