TABLE 4.

Multivariable-adjusted associations of HIV viral load with rapid kidney function decline by eGFR_cys in HIV-infected WIHS participants.

	Unadjusted IRR (95% CI)	P Value	Adjusted without serum albumin** IRR (95% CI)	P Value	Adjusted with serum albumin** IRR (95% CI)	P Value
Baseline HIV RNA, per 10-fold greater	1.38 (1.06–1.79)	0.02	1.56 (1.19–2.06)	0.001	1.39 (1.11–1.73)	0.003
Mean HIV RNA, per 10-fold greater	1.44 (1.02–2.01)	0.04	1.46 (1.10–1.94)	0.009	1.31 (1.02–1.67)	0.03

Note: Rapid kidney function decline defined as 5% or more per year, using baseline and final eGFRcys Results reported as relative risk of rapid kidney function decline (95% CI)). Estimates are calculated from generalized estimating equation relative risk regression models.

^**Models control for age, race, HIV RNA, CD4, HCV, DM, anti-retroviral therapy use, baseline estimated glomerular filtration rate, systolic and diastolic blood pressures, body mass indexI, ACR, and study site. For ACR as a predictor instead of adjusting for ACR the full model adjusts for serum albumin concentration. Anti-retroviral therapy included current combination antiretroviral therapy use, current nucleoside reverse transcriptase inhibitor use, current non-nucleoside reverse transcriptase inhibitor use, and current protease inhibitor use

ACR, albumin-creatinine ratio; CI, confidence interval; eGFR_cys, cystatin C–based estimated glomerular filtration rate; IRR, incidence rate ratio; Women’s Interagency HIV Study (WIHS),