Table II.

Table of analyzed residues and their proposed interaction functions to the structure of LeuT listed along with the original publication that proposed the interaction and/or function.

Residue(s)	Proposed Function	Original Reference
R30–D404	Extracellular Salt Bridge Gate	1
Y108–F253	Extracellular Aromatic Gate	1
R5–D369	Intracellular Salt Bridge Gate	55
N21–S256	Hydrogen Bond Interaction between TM1 and TM6	56
D401–A319	Distance to changes to close access to extracellular vestibule. Possible hydrogen bond.	30
R5–Y268	Intracellular cation–π interaction to stabilize a growing distance between R5–D369.	5;30