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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Alcohol Clin Exp Res. 2014 Jul 28;38(9):2323–2330. doi: 10.1111/acer.12497

Fig. 3. A schematic diagram describing how male and female germ lines are created to study transgeneational effects of fetal alcohol on stress axis.

Fig. 3

Mmale germline (AFM) was created by breeding male fetal alcohol exposed rats and their male offspring with normal females, and a female germline (AFF) was created by breeding female fetal alcohol exposed rats and their female offspring with normal males. As fetal alcohol exposure causes heritable sex-linked changes in Pomc expression in male rats, the possibility is raised that a sex-linked decrease in Pomc expression caused by fetal alcohol exposure (indicated by the red line on the short p arms of the Y chromosome), creating the transgenerational pattern observed.