Figure 2. Effects of GE and its active constituents on the activity of (A) CYP2B6 with substrate, bupropion and (B) CYP2C8 with substrate, amodiaquine upon incubation with human liver microsomes.

The corresponding positive controls (Ai) ticlopidine and (Bi) quercetin activities were tested followed by (Aii, Bii) 6G, 8G, 10G, 6S and (Aiii, Biii) GE. Data shown are averages of duplicate experiments for GE and positive controls.