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. 2014 Sep 24;9(9):e108577. doi: 10.1371/journal.pone.0108577

Figure 3. Western diet-induced Glucose intolerance is attenuated in mice receiving non-absorbable antibiotics or curcumin.

Figure 3

Ten week old LDLR−/− mice were fed ad libitum High Fat High Cholesterol containing Western type diet (TD 88137) for 16 weeks with or without supplementation with non-absorbable antibiotics (Panels A and C) or curcumin (Panels B and D). Panels A and B: Intraperitoneal glucose tolerance tests were performed as described under Methods. Blood glucose levels at indicated times are shown (Mean ± SEM, n = 6). Panels C and D: Area under the curve was calculated using GraphPad Prism and data are presented as Mean ± SEM, n = 6. *P<0.05. One way ANOVA with Bonferroni post-hoc correction was also performed using Western diet fed mice as controls (P<0.018) but no significant difference (P>0.05) was observed between groups supplemented with either antibiotics or curcumin indicative of similar effects of these two treatments.