Figure 1. Deletion of Saa3 attenuates weight gain on a HFHSC diet.

(A) Male and (B) female Saa3 ^+/+ and Saa3 ^−/− mice were fed chow or a high fat, high sucrose + cholesterol (HFHSC) diet for 16 weeks, and weekly body weights recorded. (C–D) Gonadal white adipose tissue (gWAT) and (E–F) liver weight were recorded at sacrifice and normalized to total body weight. n = 6–15 mice per group. *P<0.05 from chow group; #P<0.05 from Saa3 ^+/+ controls. WT: Saa3 ^+/+; KO: Saa3 ^−/−.