Table 2.

Association between Sleep Duration and White Matter Hyperintensity Volume.

Outcome: Log-WMHV	Model 1		Model 2		Model 3		Model 4
Sleep duration	β (SE) per hour	p	β (SE) per hour	p	β (SE) per hour	p	β (SE) per hour	p
Centered at 7 h	0.035 (0.015)	0.022	0.034 (0.015)	0.022	0.035 (0.015)	0.023	0.034 (0.015)	0.027
Categorical
< 6 hours	− 0.054 (0.058)	0.354	− 0.046 (0.057)	0.418	−0.046 (0.057)	0.421	−0.045 (0.057)	0.43
6– < 9 hours	--		--	--	--	--	--	--
≥ 9 hours	0.217 (0.084)	0.010	0.202 (0.083)	0.015	0.185 (0.084)	0.027	0.176 (0.084)	0.035
Outcome: Large WMH	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI
< 6 hours	0.87	0.66–1.13	0.88	0.67–1.16	0.88	0.66–1.15	0.88	0.66–1.16
6– < 9 hours	--	--	--	--	--	--	--	--
≥ 9 hours	1.55	1.13–2.28	1.56	1.15–2.31	1.47	0.98–2.19*	1.43	0.96–2.14^

Model 1: Adjusted for age at MRI.

Model 2: As Model 1, sex, year of education, race/ethnicity, Medicaid or no insurance and obesity.

Model 3: As Model 2, moderate alcohol, former smoker, current smoker, diabetes, hypertension and cardiac disease.

Model 4: As Model 3, habitual snoring and daytime sleepiness.

^*p=0.058

^{^}p=0.07