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Rate constants for folding past the commitment point for P3-weakening ribozyme mutants.
| Ribozyme | kfold (min–1) | % Native (Initial) | % Native (End) |
|---|---|---|---|
| Wild Type | 1.4 ± 0.2 | 10.1 ± 0.5 | 21.0 ± 0.4 |
| C98U | 0.5 ± 0.1 | 17.2 ± 0.4 | 29 ± 1 |
| C99U | 0.5 ± 0.1 | 23 ± 1 | 38 ± 3 |
| G100A | 0.47 ± 0.09 | 9 ± 1 | 21 ± 6 |
| G272A | 0.45 ± 0.05 | 22 ± 2 | 32 ± 3 |
| C274G | 1.4 ± 0.4 | 23 ± 2 | 37 ± 1 |
| U277G | 0.4 ± 0.1 | 40 ± 3 | 53 ± 4 |
Uncertainties are shown as the standard errors from at least four experiments.
