Table 3.
Randomized controlled trials comparing STN and GPi DBS
| Author, year | Number of patients | Follow up | Side | Similar results | Differences in results |
|---|---|---|---|---|---|
| Anderson et al., 2005 [115] |
20 |
12 months |
Bilateral |
-Motor symptoms |
-Greater decrease in dopaminergic drug dosage with STN. |
| |
-Cognitive and behavioral complications exclusively with STN. |
||||
| Okun et al., 2009 [116] |
45 |
7 months |
Unilateral |
-Motor symptoms. |
-Worse verbal fluency with STN. |
| -Side effects including mood and cognition. |
-Greater improvement in QOL with GPi [117]. |
||||
| |
-Higher risk to require controlateral DBS implant in STN group [112]. |
||||
| Follett et al., 2010 [57] |
299 |
24 months |
Bilateral |
-Motor symptoms. |
-Greater decrease in dopaminergic drug dosage with STN. |
| -Side effects profile. |
-Worse decline in visuomotor processing with STN |
||||
| -Depression improved with GPi but worsened with STN. | |||||
| Weaver et al., 2012 [118] |
159 |
36 months |
Bilateral |
-Motor symptoms. |
-Greater decrease in dopaminergic drug with STN. |
| -Side effects profile. |
-Worse cognitive performance with STN |
||||
| Odekerken et al., 2013 [119] | 128 | 12 months | Bilateral | -Quality of life. |
-Greater decrease in dopaminergic drug dosage with STN. |
| -Cognitive, psychiatric and behavioral side effects |
-Greater improvement in the OFF phase motor score with STN |
||||
| - Greater improvement in disability with STN |
Legend: STN: subthalamic nucleus; GPi: Globus pallidum pars interna; DBS: deep brain stimulation; QOL: quality of life.